Publications: 2003-Present

Sterol-modified phospholipids: cholesterol and phospholipid chimeras with improved biomembrane properties.
Huang Z, Szoka FC Jr.
J Am Chem Soc. 2008 Nov 19;130(46):15702-12. Epub 2008 Oct 25.

Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor.
Platt VM, Szoka FC Jr.
Mol Pharm. 2008 Jul-Aug;5(4):474-86. Epub 2008 Jun 3. Review.

HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery.
MacKay JA, Li W, Huang Z, Dy EE, Huynh G, Tihan T, Collins R, Deen DF, Szoka FC Jr.
Mol Ther. 2008 May;16(5):893-900. Epub 2008 Mar 11.

Reconstitution of the M13 major coat protein and its transmembrane peptide segment on a DNA template.
Li W, Suez I, Szoka FC Jr.
Biochemistry. 2007 Jul 24;46(29):8579-91. Epub 2007 Jun 27.

Lipid-based nanoparticles for nucleic acid delivery.
Li W, Szoka FC Jr.
Pharm Res. 2007 Mar;24(3):438-49. Review.

Retro-convection enhanced delivery to increase blood to brain transfer of macromolecules.
Huynh GH, Ozawa T, Deen DF, Tihan T, Szoka FC Jr.
Brain Res. 2007 Jan 12;1128(1):181-90. Epub 2006 Nov 22.

Facile synthesis of multivalent nitrilotriacetic acid (NTA) and NTA conjugates for analytical and drug delivery applications.
Huang Z, Park JI, Watson DS, Hwang P, Szoka FC Jr.
Bioconjug Chem. 2006 Nov-Dec;17(6):1592-600.

An intramolecular cyclization reaction is responsible for the in vivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin.
Lee CC, Cramer AT, Szoka FC Jr, Fréchet JM.
Bioconjug Chem. 2006 Sep-Oct;17(5):1364-8.

Efficient synthesis of an aldehyde functionalized hyaluronic acid and its application in the preparation of hyaluronan-lipid conjugates.
Ruhela D, Riviere K, Szoka FC Jr.
Bioconjug Chem. 2006 Sep-Oct;17(5):1360-3.

Acid-triggered transformation of diortho ester phosphocholine liposome.
Huang Z, Guo X, Li W, MacKay JA, Szoka FC Jr.
J Am Chem Soc. 2006 Jan 11;128(1):60-1.

Barriers to carrier mediated drug and gene delivery to brain tumors.
Huynh GH, Deen DF, Szoka FC Jr.
J Control Release. 2006 Jan 10;110(2):236-59. Epub 2005 Nov 28. Review.

Identification of a deoxyribonuclease I inhibitor from a phage-peptide library.
Choi SJ, Sperinde JJ, Szoka FC Jr.
Mol Cells. 2005 Feb 28;19(1):54-9.

Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers.
Huang Z, Li W, MacKay JA, Szoka FC Jr.
Mol Ther. 2005 Mar;11(3):409-17.

Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating.
MacKay JA, Deen DF, Szoka FC Jr.
Brain Res. 2005 Feb 28;1035(2):139-53. Epub 2005 Jan 28.

Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery.
Li W, Huang Z, MacKay JA, Grube S, Szoka FC Jr.
J Gene Med. 2005 Jan;7(1):67-79.

Toroid formation in charge neutralized flexible or semi-flexible biopolymers: potential pathway for assembly of DNA carriers.
Tang MX, Li W, Szoka FC Jr.
J Gene Med. 2005 Mar;7(3):334-42.

Interactions of hyaluronan-targeted liposomes with cultured cells: modeling of binding and endocytosis.
Eliaz RE, Nir S, Szoka FC Jr.
Methods Enzymol. 2004;387:16-33. No abstract available.

GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery.
Li W, Nicol F, Szoka FC Jr.
Adv Drug Deliv Rev. 2004 Apr 23;56(7):967-85. Review.

Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes.
Eliaz RE, Nir S, Marty C, Szoka FC Jr.
Cancer Res. 2004 Jan 15;64(2):711-8.

Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes.
Sonawane ND, Szoka FC Jr, Verkman AS.
J Biol Chem. 2003 Nov 7;278(45):44826-31. Epub 2003 Aug 27.