Our scientists are uncovering the genetic reasons why people respond differently to drugs. The goal is safer, more effective therapies for populations and individuals.
The large amount of publicly available human DNA sequence data and rapid advances in genomic technologies have stimulated research into the genetic basis of drug response and the use of genetic models in drug discovery and development. Our scientists were early leaders in the field of pharmacogenomics and in translating their discoveries to better use of therapeutics in patients. They are involved in:
- A large international research program exploring membrane transporter pharmacogenetics
- Individual projects in asthma, diabetes, HIV, obesity, and cancer pharmacogenetics
- Studies to explore the significance of regions of the genome that are highly conserved in evolution and factors regulating the activity and toxicity of neuroactive agents
- DNA microarray applications to study gene expression patterns (genetic signatures) in human tumors and to aid in the development of diagnostics and therapeutics for the treatment of cancer
- The use of model organisms to predict behavior, including behavior elicited by substances of abuse.
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