Pharmacogenomics

The large amount of publicly available human DNA sequence data and rapid advances in genomic technologies have stimulated research into the genetic basis of drug response and the use of genetic models in drug discovery and development. Our scientists were early leaders in the field of pharmacogenomics and in translating their discoveries to better use of therapeutics in patients. They are involved in:

• A large international research program exploring membrane transporter pharmacogenetics
• Individual projects in asthma, diabetes, HIV, obesity, and cancer pharmacogenetics
• Studies to explore the significance of regions of the genome that are highly conserved in evolution and factors regulating the activity and toxicity of neuroactive agents
• DNA microarray applications to study gene expression patterns (genetic signatures) in human tumors and to aid in the development of diagnostics and therapeutics for the treatment of cancer
• The use of model organisms to predict behavior, including behavior elicited by substances of abuse.

	Nadav Ahituv, PhD Assistant Professor
	Esteban González Burchard, MD, MPH Associate Professor Joint appointment: Medicine, School of Medicine
	Xin Chen, PhD Associate Adjunct Professor
	Kathy Giacomini, PhD Professor and Co-chair Joint appointments: Cellular and Molecular Pharmacology, School of Medicine; Pharmaceutical Chemistry, School of Pharmacy
	Su Guo, PhD Associate Professor Joint appointment: Pharmaceutical Chemistry, School of Pharmacy
	Deanna Kroetz, PhD Professor Joint appointment: Pharmaceutical Chemistry, School of Pharmacy

Name	Title	Joint Appointments
Nadav Ahituv, PhD	Assistant Professor			X
Esteban González Burchard, MD, MPH	Associate Professor	Medicine, School of Medicine		X
Xin Chen, PhD	Associate Adjunct Professor			X
Kathy Giacomini, PhD	Professor and Co-chair	Cellular and Molecular Pharmacology, School of Medicine; Pharmaceutical Chemistry, School of Pharmacy		X			X
Su Guo, PhD	Associate Professor	Pharmaceutical Chemistry, School of Pharmacy		X
Deanna Kroetz, PhD	Professor	Pharmaceutical Chemistry, School of Pharmacy		X

Image credit: all images © majedphoto.com except Crowd down Stockton street: niallkennedy. Some faculty member photos: UCSF School of Pharmacy faculty members.