Alan S. Verkman,
M.D., Ph.D.
Professor of Medicine and Physiology

Contact Information:
Phone: (415) 476-8530
Fax: (415) 665-3847
Box 0521, HSE-1246
verkman@itsa.ucsf.edu

Links:
Lab website
PIBS website

Publications

Biology of membrane transport

Biology of membrane transport, focusing on aquaporin water channels and CFTR chloride channels in cystic fibrosis. Drug discovery of aquaporin inhibitors and CFTR activators. Transgenic mouse models of aquaporin deficiency. Solute and macromolecule diffusion in living cells. Methods in the lab include: high-throughput drug screening, organic synthesis, state-of-the-art fluorescence microscopy including photobleaching recovery and fluorescence correlation spectroscopy, physiology of transgenic mouse models.

Selected Publications:
Galietta, L.J.V., M.F. Springsteel, M. Eda, E.J. Niedzinski, K. By, M.J. Haddadin, M.J. Kurth, M.H. Nantz and A.S. Verkman (2001). Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. J. Biol. Chem. 276:19723-19728.

Jayaraman, N.S. Joo, B. Reitz, J.J. Wine and A.S. Verkman (2001). Submucosal gland secretions in airways from cystic fibrosis patients have normal salt and pH but elevated viscosity. Proc. Natl. Acad. Sci. U.S.A. 98:8119-8123.

Haggie, P.M., B.A. Stanton and A.S. Verkman (2002). Diffusional mobility of DF508-CFTR in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras. J. Biol. Chem. 277:16419-16425

Verkman, A.S. (2002). Solute and macromolecule diffusion in aqueous compartments of living cells. Trends Biochem. Sci. 27:27-33.