Su Guo, Ph.D.
Associate Professor
of Biopharmaceutical
Sciences and
Pharmaceutical Chemistry



Contact Information:
guos@pharmacy.ucsf.edu
Tel: (415) 502-4949
Fax: (415) 502-8177
1550 4th Street
Rock Hall, Room 484D
Box 2811

Links:
Guo Lab Website
Neuroscience
PIBS
Wheeler Center for the Neurobiology of Addiction

Publications
Selected

Molecular and pharmacogenetic analysis of neural development and function and related disorders

Our research interest is to elucidate the molecular and cellular mechanisms by which the vertebrate nervous system is established and exert their function, with an emphasis on the fore- and mid-brain and monoamine (dopamine, noradrenaline, and serotonin) transmitter systems. Our approach is to apply the power of molecular genetics, in combination with pharmacological and behavioral analyses to the vertebrate model organism, the zebrafish danio rerio. In addition, we employ mammalian stem cells as an in vitro model to understand human development, disorders, and identify biologically or therapeutically potent small molecule compounds. Our research will not only provide important insights into fundamentals of the formation and function of the brain, but may also help understand and treat neurological disorders including autism, Parkinson's disease, anxiety/depression, and addiction.

Selected Publications:

Peng, J., Wagle, M., Mueller, T., Mathur, P., Lockwood, B.L., Bretaud, S., Guo S. (2009) Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. J Neurosci. 29(26):8408-18. PMID: 19571131

Berberoglu, M.A., Dong, Z., Mueller, T., Guo, S. (2009) fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene Expr Patterns. Jun 12. [Epub ahead of print]. PMID: 19524703

Persampieri, J., Ritter, D.I., Lees, D., Lehoczky, J., Li, Q., Guo, S., Chuang, J.H. (2008) cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation. Bioinformatics 24(20):2418-9. PMID: 18718943

Jeong, J., Einhorn, Z., Mathur, P., Chen, L., Lee, S., Kawakami, K., and Guo, S. (2007) Patterning the zebrafish diencephalon by the conserved zinc finger protein Fezl. Development 134, 127-136. PMID: 17164418

Wang, X., Yang N., Uno, E., Roeder, R.G., and Guo, S. (2006) A subunit of the Mediator complex regulates vertebrate neuronal development. Proc. Natl. Acad. Sci. 103, 17284-9. PMID: 17088561

Jeong, J., Einhorn, Z., Mercurio, S., Lee, S., Lau, B., Mione, M., Wilson, S.W., and Guo, S. (2006) Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl. Proc. Natl. Acad. Sci. 103, 5143-5148. PMID: 16549779