San Francisco, CA March 17–19, 2008
Mission Bay Conference Center
1675 Owens St
University of California, San Francisco
Mission Bay Campus
The Center for Drug Development Science (CDDS) is happy to announce the NONMEM Intermediate Workshop co-sponsored with the pharmacometrics group at Uppsala University. The Uppsala group has been involved in developing NONMEM models and methodology for over fifteen years. During the last decade they have been involved in the testing and evaluation of NONMEM VI as it has been developed and several research projects have focused on new functionality in NONMEM VI. In parallel, diagnostics for model building have been developed, evaluated and integrated into NONMEM VI-adapted versions of the programs Perl-speaks-NONMEM (PsN) and Xpose 4 (described below). In this course the Uppsala group will present some of the most exciting new features of NONMEM VI and how these tools can be used in the development and evaluation of non-linear mixed effects models.
The course will last for 3 days and consists of both lectures and hands-on computer exercises. Participants will use NONMEM VI, PsN and Xpose 4. PsN and Xpose 4 are freeware and may be installed on participants' computers for use after the course. In addition to the agenda below consultation sessions will be offered during each day of the course.
Having used NONMEM with an understanding of population PK-PD modeling and/or having attended a NONMEM basic workshop
Prof. Mats Karlsson
Mats Karlsson is professor of Pharmacometrics at Uppsala University, Sweden where he leads a research group of about twenty modelers. He received his PhD in pharmacokinetics from this university in 1989 and has been a research fellow at University of Glasgow and University of California, San Francisco, and a visiting professor at Georgetown University, Washington DC. He has received the Giorgio Segre Prize from EUFEPS and is editor for the Journal of Pharmacokinetics and Pharmacodynamics. His research interests focus on methodological aspects of non-linear mixed effects model building and applied PKPD modeling. He has published over one hundred original research articles in the area of PK and PKPD.
Dr Andrew Hooker
Andrew Hooker is an assistant professor of pharmacometrics at Uppsala University, Sweden. Andrew received his PhD in Bioengineering from the University of Washington, Seattle, USA in 2003, and then moved to Sweden as a Pfizer post-doctoral fellow at Uppsala University. His research focuses on methodological problems associated with building and evaluating pharmacometric models as well as optimal experimental design. Andrew is a primary developer of both Xpose 4 and the optimal design program PopED.
Rada Savic joined the Pharmacometric research group at Uppsala University, Sweden in 2003 after receiving her pharmacist degree from University of Belgrade, Serbia. Since then, she has been actively working on evaluating new features of NONMEM VI. Her research interests focus on nonparametric methods for population analysis, improved diagnostics for NONMEM VI and development of new absorption models.
The course will emphasize hands on training, with the participants working on their own computers. All programs will run from an USB memory-stick and participants will not be required to install any programs on their computer. Participants are encouraged to bring their own data sets and NONMEM models to work with during the hands-on sessions. NOTE: All participants must bring their own laptops.
Xpose 4 is a model building aid for population analysis using NONMEM. Xpose produces various plots and analyses to facilitate data set checkout, goodness-of-fit analysis, model exploration and visualization, model diagnostics, candidate covariate identification and model comparison. Xpose 4 is written in the programming language R with a modular and object oriented design and allows for integration into nearly any model building platform. New functionality in Xpose 4 allows the user to create simulation based reference diagnostics, compute the conditional weighted residuals and modify standard Xpose graphics to create publication quality figures. Xpose 4 also makes use of the new features in NONMEM VI including the visualization of non-parametric parameter distributions and individual objective function contributions. Xpose is freely available at xpose.sf.net.
Perl-speaks-NONMEM (PsN) non-linear mixed effect models using NONMEM. The functionality ranges from simpler tasks such as parameter estimate extraction from output files, data file sub setting and resampling, to advanced computer-intensive statistical methods. PsN includes both stand-alone tools as well as development libraries for method developers. PsN is freely available at psn.sf.net.
Registration fees include: syllabus; morning and afternoon refreshment breaks and lunches plus an evening reception.
Mission Bay Conference Center
1675 Owens Street
University of California Mission Bay Campus
San Francisco, CA
Parking Vouchers at UCSF parking ramp will be provided for anyone who drives to the Conference Center
Nearest to MBCC:
$189.00/Standard , $239/View Room
$249.00/Deluxe City View Room
$279.00/Superior Water View Room
$309.00/Deluxe Water Front Room
$275.00/ Superior Room
May 25-Aug 31 2007 $149.00
Sept 1-Dec 31 2007 $139.00
Call for rates.
Please click here to register online. Enrollment is limited to 50, so prospective participants are encouraged to register well in advance.
Advanced NONMEM workshop – March 17–19, 2008 at Mission Bay Conference Center, San Francisco, CA.
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