NONMEM Intermediate Workshop:

New features and advanced methods for model building and evaluation in NONMEM VI

San Francisco, CA March 17–19, 2008
Mission Bay Conference Center
1675 Owens St
University of California, San Francisco
Mission Bay Campus

Overview

The Center for Drug Development Science (CDDS) is happy to announce the NONMEM Intermediate Workshop co-sponsored with the pharmacometrics group at Uppsala University. The Uppsala group has been involved in developing NONMEM models and methodology for over fifteen years. During the last decade they have been involved in the testing and evaluation of NONMEM VI as it has been developed and several research projects have focused on new functionality in NONMEM VI. In parallel, diagnostics for model building have been developed, evaluated and integrated into NONMEM VI-adapted versions of the programs Perl-speaks-NONMEM (PsN) and Xpose 4 (described below). In this course the Uppsala group will present some of the most exciting new features of NONMEM VI and how these tools can be used in the development and evaluation of non-linear mixed effects models.

Agenda (3 full days)

The course will last for 3 days and consists of both lectures and hands-on computer exercises. Participants will use NONMEM VI, PsN and Xpose 4. PsN and Xpose 4 are freeware and may be installed on participants' computers for use after the course. In addition to the agenda below consultation sessions will be offered during each day of the course.

Day 1 — Model building and diagnostics using NONMEM VI with PsN and XPOSE 4

• Introduction to new features of NONMEM VI
• Improved model building and diagnostics using PsN and XPOSE 4
• • Automation of NONMEM VI runs
  • Introduction to diagnostics for NONMEM VI runs
  • Shrinkage and Empirical Bayes estimates based diagnostics
  • Simulation based reference diagnostics
• Hands-on computer exercises with NONMEM VI, PsN and Xpose

Day 2 — Model building and diagnostics using NONMEM VI with PsN and XPOSE 4

• Conditional weighted residuals
• Bootstrapping
• Case deletion diagnostics
• Visual and numerical predictive checks
• Hands-on computer exercises with NONMEM VI, PsN and Xpose

Day 3 — Advanced methods in NONMEM VI

• The use of prior information on parameter values in NONMEM evaluations
• Using nonparametric parameter estimation in model building using NONMEM VI
• Simultaneous modeling of continuous and categorical data
• Handling data below the limit of quantification (BLQ)
• Hands-on computer exercises with NONMEM VI, PsN and Xpose

Prerequisite:

Having used NONMEM with an understanding of population PK-PD modeling and/or having attended a NONMEM basic workshop

Instructors

Prof. Mats Karlsson
Mats Karlsson is professor of Pharmacometrics at Uppsala University, Sweden where he leads a research group of about twenty modelers. He received his PhD in pharmacokinetics from this university in 1989 and has been a research fellow at University of Glasgow and University of California, San Francisco, and a visiting professor at Georgetown University, Washington DC. He has received the Giorgio Segre Prize from EUFEPS and is editor for the Journal of Pharmacokinetics and Pharmacodynamics. His research interests focus on methodological aspects of non-linear mixed effects model building and applied PKPD modeling. He has published over one hundred original research articles in the area of PK and PKPD.

Dr Andrew Hooker
Andrew Hooker is an assistant professor of pharmacometrics at Uppsala University, Sweden. Andrew received his PhD in Bioengineering from the University of Washington, Seattle, USA in 2003, and then moved to Sweden as a Pfizer post-doctoral fellow at Uppsala University. His research focuses on methodological problems associated with building and evaluating pharmacometric models as well as optimal experimental design. Andrew is a primary developer of both Xpose 4 and the optimal design program PopED.

Rada Savic
Rada Savic joined the Pharmacometric research group at Uppsala University, Sweden in 2003 after receiving her pharmacist degree from University of Belgrade, Serbia. Since then, she has been actively working on evaluating new features of NONMEM VI. Her research interests focus on nonparametric methods for population analysis, improved diagnostics for NONMEM VI and development of new absorption models.

Details

The course will emphasize hands on training, with the participants working on their own computers. All programs will run from an USB memory-stick and participants will not be required to install any programs on their computer. Participants are encouraged to bring their own data sets and NONMEM models to work with during the hands-on sessions. NOTE: All participants must bring their own laptops.

Xpose 4 is a model building aid for population analysis using NONMEM. Xpose produces various plots and analyses to facilitate data set checkout, goodness-of-fit analysis, model exploration and visualization, model diagnostics, candidate covariate identification and model comparison. Xpose 4 is written in the programming language R with a modular and object oriented design and allows for integration into nearly any model building platform. New functionality in Xpose 4 allows the user to create simulation based reference diagnostics, compute the conditional weighted residuals and modify standard Xpose graphics to create publication quality figures. Xpose 4 also makes use of the new features in NONMEM VI including the visualization of non-parametric parameter distributions and individual objective function contributions. Xpose is freely available at xpose.sf.net.

Perl-speaks-NONMEM (PsN) non-linear mixed effect models using NONMEM. The functionality ranges from simpler tasks such as parameter estimate extraction from output files, data file sub setting and resampling, to advanced computer-intensive statistical methods. PsN includes both stand-alone tools as well as development libraries for method developers. PsN is freely available at psn.sf.net.

Registration Fees:

Industry: $2,300

Reduced fees for Academic/Gov't: $1,600

Registration fees include: syllabus; morning and afternoon refreshment breaks and lunches plus an evening reception.

• Attendance is strictly limited to 50.
• Number of "reduced fees" for Academics and students is limited to a total of 8.
• Registration and academic fees will be offered on the basis of first come, first served.

Hotel Workshop and City:

Workshop location:
Mission Bay Conference Center
1675 Owens Street
University of California Mission Bay Campus
San Francisco, CA

Parking Vouchers at UCSF parking ramp will be provided for anyone who drives to the Conference Center

Sleeping Rooms:

Nearest to MBCC:

1) Harbor Court Hotel
165 Steuart Street
San Francisco, CA 94105
http://www.harborcourthotel.com

$189.00/Standard , $239/View Room
RESERVATION: 800-346-0555

2) Hilton San Francisco Financial District
750 Kearny Street
San Francisco, CA 94108
http://www.sanfranciscohiltonhotel.com/

$209/Deluxe Room
$249/Upgraded Room,
RESERVATION: 800-424-8292

3) Hotel Vitale
Eight Mission Street
San Francisco, CA 94105
http://www.hotelvitale.com

$249.00/Deluxe City View Room
$279.00/Superior Water View Room
$309.00/Deluxe Water Front Room
RESERVATION: 888-890-8688

4) Le Meridien San Francisco
333 Battery Street
San Francisco, CA 94111
http://www.lemeridien.com/sanfrancisco

$275.00/ Superior Room
RESERVATION: 888-237-4184

5) Fisherman's Wharf Area
Holiday Inn Express Hotel & Suites
Fisherman's Wharf
550 North Point Street
San Francisco, CA 94133

May 25-Aug 31 2007 $149.00
Sept 1-Dec 31 2007 $139.00
RESERVATION: 415-409-4600

6) Downtown/Union Square Area
Hotel Nikko San Francisco
222 Mason Street
San Francisco, CA 94102
http://www.hotelnikkosf.com

$185.00/Deluxe Room
RESERVATION: 800-248-3308

7) The Handlery Union Square Hotel
351 Geary St.
San Francisco, CA. 94102

Call for rates.
RESERVATION: 415-321-7568

Workshop Organizing Committee:

Julie Nelson, CDDS-UCSF, Washington DC: julie.nelson@ucsf.edu
Howard Lee, CDDS-UCSF, Washington DC: howard.lee@ucsf.edu
Nancy Sambol, CDDS-UCSF, San Fransisco: nancy.sambol@ucsf.edu

TO REGISTER FOR NONMEM intermediate workshop
San Francisco, CA March 17-19, 2008:

Please click here to register online. Enrollment is limited to 50, so prospective participants are encouraged to register well in advance.

Course Fee:

Industry: $2,300

Academic/Student/Gov't: $1,600

               

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